Clinical pharmacology studies with acenocoumarol
Hirtz, J.; Le Roux, Y.; Jaouen, A.; Richard, J.; Blatrix, C.; Thébault, J.J.; Schoeller, J.P.
International Journal of Clinical Pharmacology and Biopharmacy 17(8): 361-365
1979
ISSN/ISBN: 0340-0026 PMID: 489204 Document Number: 148685
In 2 different studies, the relation between plasma concentrations of acenocoumarol, an anticoagulant, and apparent prothrombin levels (Quick test) was investigated, using a new specific analytical method for the assay of the drug. The prothrombin level appeared independent of the plasma concentration of the drug, which is higher in old patients (over 70 yr) than in younger patients (under 51 yr).