Solubilization of the photosensitizers TPCS (2a) and TPPS (2a) in aqueous media evaluated by time-resolved fluorescence analysis
Nardo, L.; Kristensen, S.; Tønnesen, H.H.; Høgset, A.; Lilletvedt, M.
Die Pharmazie 67(7): 598-600
2012
ISSN/ISBN: 0031-7144 PMID: 22888515 Document Number: 660216
The pH-dependent aggregation of the novel photosensitizer TPCS(2a) is investigated at low concentration (c = 10(-6) M) in aqueous media by means of time-correlated single-photon counting, and compared to that of the chemically related photosensitizer TPPS(2a). The efficacy of selected solubilizers, i.e., various nonionic Pluronic block copolymers and the nonionic surfactant Tween 80, in inhibiting aggregation of the two photosensitizers is evaluated, which is important for the further formulation of TPCS(2a).