Solubilization and interaction of naproxen with polyvinylpyrrolidone in aqueous solution and in the solid state
Bettinetti, G.P.; Mura, P.; Liguori, A.; Bramanti, G.; Giordano, F.
Il Farmaco; Edizione Pratica 43(11): 331-343
1988
ISSN/ISBN: 0430-0912 PMID: 3243349 Document Number: 322996
The results of a study aimed at improving the dissolution properties of naproxen via solid dispersion systems prepared by colyophilization with polyvinylpyrrolidone (mean mol. wt. 25000) are reported. Drug-polymer interaction models both in aqueous solution and in the solid state are proposed.
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