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Oseltamivir analog with boron cluster modulator

Adamska, A.; Olejniczak, A.B.; Zwoliński, K.; Szczepek, W.J.; Król, E.; Szewczyk, B.ła.; Grynkiewicz, G.; Leśnikowski, Z.J.

Acta Poloniae Pharmaceutica 69(6): 1218-1223

2012

ISSN/ISBN: 0001-6837
PMID: 23285684
Document Number: 657871
Synthesis of novel neuraminidase inhibitor -- carborane ester of oseltamivir carboxylic acid is described, and its physicochemical and spectral characteristics is provided. Surprisingly, carborane analog of oseltamivir is of an order of magnitude less active than its precursor, the corresponding ethyl ester, which is the active principle of pharmaceutical preparations used in influenza prophylactics and therapy.

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