Primitive neuroectodermal tumor/Ewing's sarcoma of the penis in children: a case report and review of the literature
Zhang, D-Wei.; Jin, M.; Zhou, C-Ju.; Song, H-Cheng.; Ma, X-Li.
Zhonghua Nan Ke Xue 18(12): 1115-1118
2012
ISSN/ISBN: 1009-3591 PMID: 23405795 Document Number: 657870
To investigate the clinical manifestations, pathological characteristics and treatment of primitive neuroectodermal tumor/Ewing's sarcoma (PNET/EWS) of the penis in children. We analyzed the clinical data of a case of PNET/EWS and reviewed relevant literature. The patient was a 5-year-old boy, admitted for penis swelling with pain for 11 months. Biopsy showed a small round cell tumor, CD99 positive by immunohistochemical staining, with EWS translocation by fluorescence in situ hybridization on molecular biological examination. The tumor was confirmed to be PNET/EWS of the penis, and disappeared after 45 weeks of chemotherapy and local radiotherapy. PNET/EWS of the penis is an extremely rare disease, with no specific clinical symptoms except penis enlargement with pain. Immunohistochemistry and molecular biological examination contribute to its diagnosis.