A case of gastric cancer with rhabdoid features showing better prognosis through S-1/CDDP chemotherapy
Mori, Y.; Kobayashi, M.; Ishihara, S.; Mizobuchi, K.; Kishi, M.; Kurosaki, T.; Miyake, S.; Watanabe, N.; Kimura, K.; Kokudo, Y.; Muraoka, A.; Tatemoto, A.; Nagasaka, T.; Tsumura, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 39(5): 829-832
2012
ISSN/ISBN: 0385-0684 PMID: 22584342 Document Number: 656405
Although gastric cancers(GCs)with rhabdoid features are rare, they are known to show a poorer prognosis compared with conventional GCs. Indeed, more than half of reported GCs with rhabdoid features died within 6 months after receiving any kind of initial treatment. Obviously, no effective chemotherapy has been reported. In this study, we present a case of GC with rhabdoid features which showed a better response to a chemotherapy, S-1/CDDP, and lived for over 12 months after the initial chemotherapy. A 75-year-old man was seen in our hospital for epigastralgia. Detailed examinations revealed that he had GC at Stage IV. Consequently, he underwent S-1/CDDP treatment. This treatment produced a good response for 6 months, minimizing the size of the primary tumor and eradicating distant metastases. Re-growth of the primary tumor without uprising distant metastasis was confirmed 8 months after the initialS -1/CDDP treatment, and the patient went through a gastrectomy for curative care. After surgery, a precise pathological examination revealed that the primary tumor possessed a poorly differentiated adenocarcinoma that contained tumor cells with typical rhabdoid features. In the end, the patient died of liver metastasis 13 months after the initial S-1/CDDP chemotherapy.