A case of gastric cancer with liver metastasis had a good reaction to S-1/CDDP chemotherapy after S-1 chemotherapy was ineffective
Uji, K.; Tamura, S.; Takeno, A.; Miki, H.; Kanemura, T.; Yanai, A.; Kobayashi, M.; Yoshioka, Y.; Teramoto, A.; Nakahira, S.; Suzuki, R.; Nakata, K.; Egawa, C.; Okamura, S.; Sugimoto, K.; Takatsuka, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 38(10): 1691-1694
2011
ISSN/ISBN: 0385-0684 PMID: 21996969 Document Number: 654426
A woman in her sixties underwent total gastrectomy for gastric cancer. The pathological diagnosis was pT3, pN3, sH0, pCY0, sP0, sM0, fStage IV. Chemotherapy with S-1 was used after surgical treatment. Because a CT scan after three courses chemotherapy showed the paraaortic lymph nodes swelling, combination chemotherapy with S-1 and docetaxel was used as a second-line chemotherapy. When the CT scan after 8 courses of this combination chemotherapy revealed multiple liver metastases, the chemotherapy was changed to CPT-11 monotherapy and paclitaxel monotherapy as the third-and fourth-line chemotherapy, respectively. In spite of those chemotherapies, the metastatic disease progressed, and therefore, combination chemotherapy with S-1 and CDDP was used as the fifth-line chemotherapy. After 6 courses of this treatment, serum CEA and CA19-9 levels dropped into the normal range. Multiple liver metastases were markedly reduced, and were considered as a partial response(PR). The patient is still alive, maintaining the effect of PR for 17 months without any adverse effects except appetite loss and vomiting of grade 2.