Diagnosis of Atrophic Gastritis from a Serum Sample
Sipponen, P.; Matti Häkönen; Alanko, A. and Osmo Suovaniemi
Clinical Laboratory 48(9-10): 505-515
2002
ISSN/ISBN: 1433-6510 PMID: 12389711 Document Number: 6554
On the basis of the levels of serum pepsinogen I (S-PGI) and gastrin-17 (S-G-17) as well as Helicobacter pylori - antibodies assayed from a blood sample it is possible to establish with high sensitivity and specificity whether the patient has gastritis, whether the gastritis is atrophic or not and in which part of the stomach the atrophic changes are located. The test enables the identifïcation of patients whose risk of gastric cancer, of the consequences of vitamin B 12 deficiency (e.g. elevated levels of homocysteine) or of peptic ulcer is considerably increased and who can then undergo gastroscopy. It also facilitates the diagnosis of non-atrophic Helicobacter gastritis enabling treatment before endoscopy. (Clin. Lab. 2002;48:505-515) DOI: Clin. Lab. 2002;48:505-515
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