Efficiency perindopril at patients with arterial hypertension and obesity
Nedogoda, S.V.; Lediaeva, A.A.; Chumachok, E.V.; Tsoma, V.V.; Mazina, G.G.; Salasiuk, A.S.
Kardiologiia 51(11): 38-44
2011
ISSN/ISBN: 0022-9040 PMID: 22117769 Document Number: 651176
We gave perindopril (10 mg/day) for 24 weeks to 30 patients with arterial hypertension and obesity and proved its ability to effectively lower arterial pressure, exert cardio-, angio-, and nephro-protection, improve parameters of lipid, carbohydrate and purine metabolisms in these patients. Moreover perindopril in these patients diminished manifestations of insulin resistance, hyperleptinemia, and inflammation; it also exerted pronounced positive effect on anthropometric parameters and percent of fat deposits. Basing on the aggregate of clinical and pharmacodynamics effects perindopril can be considered the drug of choice for treatment of arterial hypertension at the background of obesity.