Top Abstract Purchase Related
Home
>
Node
>
Subnode

Secondary Prevention of Arterial Hypertension in Vehicle Drivers--Efficiency, Specific Safety

Elgarov, A.A.; Aramisova, R.M.; Elgarov, M.A.; Kalmykova, M.A.

Klinicheskaia Meditsina 93(4): 31-38

2015

ISSN/ISBN: 0023-2149
PMID: 26155707
Document Number: 680935
To estimate effectiveness and safety of pharmacotherapy in vehicle drivers with arterial hypertension (AH). 432 patients with grade I-III AH including 82 with cardiovascular complications largely of II and III grade were under observation during 2.5-4 months using clinical and instrumental methods (24hr AP & ECG monitoring) as well as psychophysiological testing (PPT). Ramipril and atenolol were efficient in 77.4 and 91.6% of the cases respectively; side effects were documented in 23.9 and 10.9%, somnolence and apathy in 13%, signs of somnolence in 2.2% of the cases. PPT revealed deterioration of the ability to drive (p < 0.05) in the patients given rampiril and the absence of its change in those receiving atenolol. Teveten (eprosartan) and diroton (lisinopril) were efficient in 94.8 and 81% of the cases but 8.6% of the patients refused to continue therapy because of side effects, such as somnolence, dry cough. Diroton deteriorated results of PPT (p < 0.05) and teveten improved them (p < 0.01). The effectiveness of isradipine (lomir), clophiline, estulic and trandolapril was 93.7, 7-87.5, 5-81.2, 2-82%. Isradipine had beneficial effect on PPT results (p<O. 01). The remaining drugs negatively influenced the rapid response system (p < 0.05 < 0.01). Therapy with nebilet and teveten in combination with indap was effective in 83.3 and 93.3% of the cases and improved professional reliability of the drivers (p < 0.05, 0.01). Assessment of efficacy and safety of pharmacotherapy in vehicle drivers must include evaluation of the degree and character of its influence on professional working ability. Beneficial effect of pharmacotherapy on the rapid response system with simultaneous normalization of AP and health status should be interpreted as evidence of specific safety and effectiveness of antihypertensive treatment.

Document emailed within 1 workday
Secure & encrypted payments

Aramisova, R.M.; El'garov, A.A. 1996: Isradipine in arterial hypertension in motor vehicle drivers Meditsina Truda i Promyshlennaia Ekologiia 8: 21-23
Novikova, T.V.; Britov, A.N.; Aleksandrov, A.A.; Shchepkin, V. 1983: Inventory of socio-psychological factors in the secondary prevention of arterial hypertension Sovetskaia Meditsina 1983(1): 62-65
Britov, A.; Alexandrov, A.; Molchanov, V.; Novikova, T.; Prokhorov, A.; Litun, I. 1982: Psychological and occupational risk factors in the secondary prevention of the arterial hypertension Activitas Nervosa Superior Suppl. 3(Pt 2): 475
Eliseeva, N.A. 1982: Results of the primary and secondary prevention of arterial hypertension among women at an industrial enterprise in Moscow Kardiologiia 22(3): 69-73
Khvorostinka, V.N.; Pasieshvili, L.M.; Biazrova, V.V. 1992: The prevalence and secondary prevention of ischemic heart disease and arterial hypertension in workers of the gas recovery industry Likars'ka Sprava 1992(5): 80-82
Kishlar', L.I.; Botnar', V.I.; Glazunov, I.S. 1991: Epidemiological situation regarding arterial hypertension after conducting 5-year program of its secondary prevention among rural population of Moldavia Kardiologiia 31(3): 78-79
Akhmedova, A.A.; Ocheredko, O.M. 2018: Substantiation of the model of clinical and economic efficiency evaluation of prevention, treatment, and dispenserization of the patients with comorbidity. The example of patients with arterial hypertension and duodenitis Wiadomosci Lekarskie 71(3 Pt 1): 479-484
Aramisova, R.M.; Elgarov, A.A. 2002: Results of gopten monotherapy in drivers having arterial hypertension Meditsina Truda i Promyshlennaia Ekologiia 4: 32-34
Popov, A.I.; Salamatina, L.V.; Prokopenko, L.V.; Buganov, A.A. 2007: Arterial hypertension and risk factors in automobile drivers of Far North Meditsina Truda i Promyshlennaia Ekologiia 2007(1): 16-22
E'lgarov, A.A.; Inarokova, A.M. 1989: Non-pharmacological methods of the treatment of initial stages of arterial hypertension in automobile drivers Gigiena Truda i Professional'nye Zabolevaniya (8): 42-44
Cambou, J.P.; Cothereau, C.; Simon, S.; Aptel, I.; Conso, F. 1998: Arterial hypertension and socioeconomic status in a representative population of French railway drivers Archives des Maladies du Coeur et des Vaisseaux 91(8): 989-993
Novokrestova, S.V.; Salamatina, L.V.; Buganov, A.A.; Umanskaia, E.L.; Shesterikova, N.V.; Mamedova, S.I. 2003: Efficiency of diovan (valsartane) in arterial hypertension patients Meditsina Truda i Promyshlennaia Ekologiia 4: 28-32
Nedogoda, S.V.; Lediaeva, A.A.; Chumachok, E.V.; Tsoma, V.V.; Mazina, G.G.; Salasiuk, A.S. 2011: Efficiency perindopril at patients with arterial hypertension and obesity Kardiologiia 51(11): 38-44
El'chaninova, S.A.; Koreniak, N.A.; Driagina, I.V.; Makarenko, V.V.; Smirnova, O.I. 2007: Endothelial injury markers as a possible criterion for the efficiency of treatment for arterial hypertension Klinicheskaia Laboratornaia Diagnostika 2: 40-42
Iskenderov, B.G.; Sisina, O.N.; Gridneva, E.V.; Lokhina, T.V. 2010: Comparative efficiency of indapamide combinations with various derivaties of calcium antagonists in patients with arterial hypertension Klinicheskaia Meditsina 88(1): 54-58
Krishnan, P.; Hashim, N.; Rani, U.; Lung, J.K. 1998: Survey on health status of heavy vehicle drivers in Klang valley Medical Journal of Malaysia 53(4): 449-451
Bischof Delaloye, A.; Delaloye, B. 1989: Radioisotope studies in secondary arterial hypertension Revue Medicale de la Suisse Romande 109(1): 17-24
Chamontin, B. 1994: Secondary arterial hypertension in adults. Etiology, physiopathology La Revue du Praticien 44(7): 953-959
Arnal, J.M.; Moneo, M.I.; Loris, C. 1987: Arterial hypertension secondary to the application of 9-alpha-fluoroprednisolone ointments Anales Espanoles de Pediatria 26(1): 65-66
Shope, J.T.; Molnar, L.J.; Elliott, M.R.; Waller, P.F. 2001: Graduated driver licensing in Michigan: early impact on motor vehicle crashes among 16-year-old drivers JAMA 286(13): 1593-1598