Comparative efficiency of indapamide combinations with various derivaties of calcium antagonists in patients with arterial hypertension
Iskenderov, B.G.; Sisina, O.N.; Gridneva, E.V.; Lokhina, T.V.
Klinicheskaia Meditsina 88(1): 54-58
2010
ISSN/ISBN: 0023-2149 PMID: 20369614 Document Number: 644571
The study included 59 patients aged 42-65 yr with grade II AH. They underwent 24 hour AP monitoring and Doppler echocardiography before and 16 weeks after onset of the study. The patients were randomly allocated to 2 groups. In group 1, they were given combined therapy with indapamide and verapamil retard. Patients of group 2 were treated with indapamide and amlodipine. AP circadian rhythm returned to normal in 83 and 78.6% of the patients in groups 1 and 2 respectively. Combined therapy in group 1 was especially beneficial for patients with type 1 left ventricular diastolic dysfunction, daily non-dipper profile, and hyperkinetic type of blood circulation. In group 2, the most pronounced changes were documented in patients with type II-III left ventricular diastolic dysfunction and hypokinetic type of circulation.