Effect of piperine on pentobarbitone induced hypnosis in rats

Mujumdar, A.M.; Dhuley, J.N.; Deshmukh, V.K.; Raman, P.H.; Thorat, S.L.; Naik, S.R.

Indian Journal of Experimental Biology 28(5): 486-487

1990


ISSN/ISBN: 0019-5189
PMID: 2401524
Document Number: 649
Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependent manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time. It is possible that, piperine inhibits liver microsomal enzyme system and thereby potentiates the pentobarbitone sleeping time.

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Effect of piperine on pentobarbitone induced hypnosis in rats