Effect of ticlopidine on streptokinase-induced thrombolysis in rats
Gryglewski, R.J.; Korbut, R.; Swies, J.; Uracz, W.
Wiener Klinische Wochenschrift 111(3): 98-102
1999
ISSN/ISBN: 0043-5325 PMID: 10093891 Document Number: 500323
Using our original assay system we found that ticlopidine (TP, 30 mg/kg i. v.) had produced a prompt thrombolysis of preformed clots in extra-corporeal circulation of anaesthetized rats. In contrast with ticlopidine streptokinase (SK, 30.000 U/kg i. v.) proved thrombogenic for an initial period of 10-30 min followed only later by the expected thrombolytic action. In ticlopidine pretreated rats the thrombogenic effect of streptokinase was eliminated, and its thrombolytic potency intensified. This is the first experimental support for a conception that a combined therapy with ticlopidine and streptokinase may restrict the "early hazard" associated with streptokinase therapy.