Ticlopidine-induced hepatitis
Chen, L.K.; Hsieh, B.H.; Chen, W.C.; Tsai, S.T.; Hou, M.C.
Zhonghua Yi Xue Za Zhi 64(1): 59-63
2001
ISSN/ISBN: 0578-1337 PMID: 11310373 Document Number: 526504
Ticlopidine is a commonly prescribed drug in cerebrovascular or cardiovascular diseases. Since the first introduction in 1970's, ticlopidine was shown to be a relatively safe drug. The adverse effects of ticlopidine were mainly bone marrow toxicity and elevation of liver function tests. Ticlopidine-induced hepatitis is rare and only 33 cases were reported in previous English literature. The 33 cases were mostly categorized in cholestatic liver injury; only 2 cases were hepatocellular. In Taiwan, a case of ticlopidine-induced cholestatic hepatitis was ever reported. Herein, we present another rare case of ticlopidine-induced hepatitis in Taiwan with the nature of hepatocellular injury.