Clinical and molecular correlation between chronic hepatitis and hepatocellular carcinoma induced by hepatitis B virus
Shapiro, I.I.; Shabrov, A.V.; Karev, V.E.; Leenman, E.E.; Kvetnoĭ, I.M.; Tsinzerling, V.A.; Sologub, T.V.
Arkhiv Patologii 67(2): 6-10
2005
ISSN/ISBN: 0004-1955 PMID: 15938110 Document Number: 588588
The role of X-gene of hepatitis B virus (HBV), telomerase gene, structural HBV proteins is considered. Both factors of the virus and those of the host are involved in hepatocarcinogenesis. The duration of chronic B hepatitis may influence mitogenic and mutagenic conditions for accumulation of occasional genetic and chromosomal damage and result in hepatocarcinoma development.
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