Serum anti-hepatitis C virus and hepatitis C virus RNA in patients with hepatocellular carcinoma
Jiang, M.D.
Zhonghua Yi Xue Za Zhi 73(3): 131-134; 189
1993
ISSN/ISBN: 0376-2491 PMID: 7686810 Document Number: 408518
Serum anti-HCV and HCV RNA (RT-PCR), possible association to the markers of hepatitis B virus (HBV-M) including HBsAg were evaluated in 48 patients with hepatocellular carcinoma (HCC). The results indicated that 13 were anti-HCV positive in HCC group and 5 in other cancers (control group, P < 0.05). Serum HCV RNA was detected in 11 patients with HCC (23%). The positive rate of HCV RNA and/or anti-HCV (HCV-M) was 38% in all HCC cases, 80% (12/15) in HBV-M (-) HCC, 58% (14/24) in HBsAg(-), 18% (6/33) in HBV-M(+), and 15% (4/24) in HBsAg(+). HBV-M and/or HCV-M was found positive in 45 patients with HCC (93.8%). Our study shows that both HBV and HCV infections are related to the development of HCC. HCV-M was found positive mostly in HBV-M negative HCC patients and serum HCV RNA replication existed in some of HCC cases.