Effect of tripterine on collagen-induced arthritis in rats
Li, H.; Jia, Y.F.; Pan, Y.; Pan, D.J.; Li, D.; Zhang, L.X.
Zhongguo Yao Li Xue Bao 18(3): 270-273
1997
ISSN/ISBN: 0253-9756 PMID: 10072949 Document Number: 481742
AIM: To study the therapeutic effect of tripterine (Tri) on collagen-induced arthritis ( CIA ). METHODS: Collagen type II (Col) 1.5 mg was injected intradermally to induce CIA in rats. Hind paw volumes of rats were measured with a water displacement method. The serum anticollagen antibody was measured by an enzyme-linked immunosorbent assay. Delayed hypersensitivity was reflected by skin response to Col. Interleukin-1 (IL-1) and interleukin-2 (IL-2) activities were evaluated by (3H)TdR uptake. Joint was evaluated histologically. RESULTS: Tri 15 and 30 mg cntdot kg-1 cntdot d-1 given ig to rats 3 d after the first sign of arthritis reduced inflammatory swelling, suppressed humoral and skin response to Col, inhibited IL-2 and IL-1 production, reduced pathological progression of joint. CONCLUSION: Tri has a therapeutic effect on CIA.