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Influence of bioflavonoids on the collagen metabolism in rats with adjuvant induced arthritis

Rao, C.N.; Rao, V.H.; Steinmann, B.

Italian Journal of Biochemistry 30(1): 54-62

1981

ISSN/ISBN: 0021-2938
PMID: 7251341
Document Number: 169932
In rats with adjuvant induced arthritis, the effect of CA or HR on the metabolism of collagen in skin was studied. In untreated animals with adjuvant induced arthritis, the synthesis of collagen is decreased, the catabolism of newly formed collagen is intensified and the conversion of soluble collagen to insoluble collagen is impaired. Bioflavonoids were found to increase the collagen synthesis, accelerate the conversion of soluble collagen to insoluble collagen and inhibit the catabolism of soluble collagen. The beneficial action of bioflavonoids on the metabolism of collagen in adjuvant induced arthritis was discussed.

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