Metabolism of the sulphated glycosamino-glycans of skin, cartilage and bone of rats with adjuvant arthritis
Exer, B.; Maier, R.
Wiener Klinische Wochenschrift 89(21): 723-727
1977
ISSN/ISBN: 0043-5325 PMID: 919559 Document Number: 118946
The time course of the quantitative changes in connective tissue of non-inflamed dorsal skin and of inflamed hind limbs was investigated by means of radioactively-labelled sulphate. Whereas the rate of incorporation of 35SO4 into the skin is reduced, its turnover in the inflamed tissue is greatly accelerated. This increase is observed both in the soft (cartilage) and hard (bone) connective tissue on both hind legs. The citric acid content of affected bone is lower than in healthy animals.