Formulation and in vitro examination of furosemide-containing suppositories and preliminary experiences of their clinical use
Regdon, G.; Fazekas, T.; Regdon, G.; Selmeczi, B.
Acta Pharmaceutica Hungarica 67(1): 19-23
1997
ISSN/ISBN: 0001-6659 PMID: 9163255 Document Number: 481743
Rectal suppositories containing Furosemide (4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid) and Furosemide Sodium were formulated with various suppository bases. The in vitro drug release of Massa Estarinum 299 proved to be the best from among the vehicles having various physical-chemical properties. The diuretic effect of the two suppositories was compared in a prospective, cross-over clinical trial including 8 patients. Both preparations have induced and increase of urine flow, which was comparable to the diuretic effect of the tablet. Thus the possibility of rectal use has been added to the modalities of therapeutic Furosemide administration.