Formulation of diazepam suppositories, results of rheological and biopharmaceutical studies. 1. Rheological study of the used suppository bases
Erós, I.; Bácskay, I.; Regdon, G.; Selmeczi, B.
Acta Pharmaceutica Hungarica 63(5): 267-275
1993
ISSN/ISBN: 0001-6659 PMID: 8249611 Document Number: 415029
The rheological properties of four lipophilic and three hydrophilic suppository bases were studied. The flow and viscosity curves, the initial, equilibrium and plastic viscosity as well as the Bingham's yield value of the systems were determined. It was found that the viscosity curves had two different parts in the examined shearing rate range: the part of greater rise described a definitive destruction of the system, while the part of smaller rise represented an equilibrium state. The values of the rheological parameters of the lipophilic and hydrophilic systems showed a definite difference, which was explained by the greater association of the hydrophilic bases.