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Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity

Ma, S.; Lv, H.; Ding, G.; Yu, S.; Chen, X.

Zhongguo Zhong Yao Za Zhi 36(13): 1769-1771

2011

ISSN/ISBN: 1001-5302
PMID: 22032141
Document Number: 648360
Six compounds were isolated from the roots of Pithecellobium lucidum by various chromatograhic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as julibroside A2 (1), 3-[ (2-acetamido-2-deoxy-beta-D-glucopyranosyl) oxy] -16alpha-hydroxyolean-12-en-28-oic acid (2), galloyl acid (3), ethyl gallate (4), (+)-catechin (5), (-)-gallocatechin gallate (6) on the basis of spectrascopic data analysis. Compounds 1-6 were isolated from Pithecellobium lucidum for the first time. Compound 2 showed selective cytoxic activity against the human cell lines A2780 with an IC50 value of 1.72 micromol x L(-1).

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