Morphogenesis of tick-borne encephalitis virus in the brain of mice infected with its persistent strains
Sobolev, S.G.; Frolova, T.V.; Pogodina, V.V.
Voprosy Virusologii 55(6): 31-35
2010
ISSN/ISBN: 0507-4088 PMID: 21381338 Document Number: 647559
The brain cells of adult albino rats underwent electron microscopic study after intracerebral infection with tickborne encephalitis virus (TBEV) strains isolated after long persistence in monkeys, Syrian hamsters, and a patient with chronic tick-borne encephalitis. The TBEV morphogenesis scheme was shown to be fundamentally similar for both high-virulent and long persistent TBEV strains. Data on the budding of newly forming particles on the degranulated membranes of the irregular endoplasmic network are presented. The morphogenesis and molecular mechanisms of TBEV reproduction call for further comprehensive studies.