Combination of S-1 and paclitaxel for advanced/recurrent gastric cancer patients with peritoneal metastasis, feasibility study (OGSG0401)
Kimura, Y.; Machida, H.; Fujitani, K.; Yamamoto, M.; Tominaga, K.; Yano, H.; Shimokawa, T.; Takiuchi, H.; Tsujinaka, T.; Furukawa, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(1): 151-155
2010
ISSN/ISBN: 0385-0684 PMID: 20087052 Document Number: 646725
The standard therapy for gastric cancer with peritoneal metastasis has remained unclear. This prospective feasibility study was aimed to investigate the efficacy and safety of S-1 plus paclitaxel for advanced/recurrent gastric cancer patients with peritoneal metastasis able to take oral feeding. Seven patients were enrolled in this study. Paclitaxel 50mg/m2 was administered on days 1 and 8. S-1 was administered orally at 40 mg/m2 bid for 14 consecutive days, followed by a 1-week rest. Overall survival, the response rate and safety were examined for efficacy and tolerability. The median survival time was 310 days. The response rate in five patients was 80. 0%. Grade 3 toxicity was observed in two patients. Combination chemotherapy of weekly paclitaxel and S-1 demonstrated efficacy and tolerable toxicity. This regimen will be one of the initial treatment options for unresectable or metastatic gastric cancer with peritoneal metastasis.