Computer simulations of the preautomatic pause in pacemaker cells of the sinoatrial node
Aliev, R.R.; Furs, A.I.
Biofizika 55(3): 496-499
2010
ISSN/ISBN: 0006-3029 PMID: 20586330 Document Number: 641748
The duration of the preautomatic pause as a function of sinoatrial node, the type of pacemaker cells, acetylcholine concentration, the duration of high-frequency stimulation, and the conductivity of gap junctions has been studied. It was found that the preautomatic pause in peripheral pacemakers occurs at a higher concentration of acetylcholine as compared with central pacemakers. The dependence of the duration of the preautomatic pause on the gap junction conductivity is a nonlinear one.