Computer simulation of fibroblast effect on electrical activity in sinoatrial node cells
Tolstokorov, A.S.; Syunyaev, R.A.; Aliev, R.R.
Biofizika 60(2): 322-329
2015
ISSN/ISBN: 0006-3029 PMID: 26016028 Document Number: 683255
Computer simulation of the electrical activity in sinoatrial node cells interacting via gap junctions with fibroblasts revealed that interaction with fibroblasts results in greater oscillation frequency of sinoatrial node cells. We have found out that fibroblasts also decrease the oscillation amplitude of the intrinsic central cells or completely suppress their spontaneous activity, while weakly affect the oscillation amplitude of peripheral cells.