Other non-motor disorders in Parkinson's disease
Marco-Llorente, J.; Rojo-Martínez, E.
Revista de Neurologia 50(Suppl 2): S75-S83
2010
ISSN/ISBN: 1576-6578 PMID: 20205147 Document Number: 640632
In addition to the classic triad (tremor, rigidity and akinesia), Parkinson's disease (PD) is also accompanied by several non-motor disorders. To carry out an updated review of these non-motor symptoms in terms of their pathophysiology, epidemiology, clinical features and treatment. Autonomic disorders such as seborrhoeic dermatitis and disorders involving sweating, fatigue, weight loss or respiratory problems (dyspnea, inspiratory stridor) are highly prevalent and very disabling symptoms. In addition, they may be the main problem in a particular phase of PD (fatigue, stridor) and condition the quality of life of patients with Parkinson. They are often neglected and remain undetected. Although they may respond to dopaminergic agents, they usually require a different therapeutic approach. Studies are needed to evaluate new therapeutic perspectives that act against the pathophysiological mechanisms of these disorders. PD affects systems other than the dopaminergic nigrostriatal. A better understanding of this pathology will make it possible to approach and optimise the treatment of the conditioning symptoms, thereby enhancing the welfare of patients with PD.