Treatment of motor fluctuations in Parkinson's disease with subcutaneous injections of apomorphine
Merello, M.; Leiguarda, R.
Medicina 55(1): 5-10
1995
ISSN/ISBN: 0025-7680 PMID: 7565037 Document Number: 439926
Sixteen patients with Parkinson's disease and severe motor fluctuations were treated with subcutaneous injections of apomorphine and followed up prospectively for a year. The use of the drug improved the number of daily "off" hours by 52%, while treatment efficacy remained constant for a year without the appearance of tolerance (ANOVA with repeated measurements:p = 0.0002). No severe adverse effect or any justifying treatment discontinuance were recorded. Apomorphine proved a safe and reliable drug for the treatment of motor fluctuations.