Motor, cognitive and affective disorders in Parkinson's disease
Vendrova, M.I.; Golubev, V.L.; Sadekov, R.A.; Veĭn, A.M.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 103(3): 13-17
2003
ISSN/ISBN: 1997-7298 PMID: 12830500 Document Number: 564567
The study aimed at investigating the ratio of movement disorders to cognitive and affective ones. The group of patients with Parkinson's disease (PD, n = 42) compared with those with brain tumors (n = 14), neurotic depression (n = 15) and normals (n = 20). Clinical, psychological and neurophysiologic (motor evoked potentials--MP) methods were used. Location of the pathological process, lesion side, severity of movement deficit and presence of cognitive and affective disorders (depression) were shown to influence an organization of movement act. Location of the pathological process determines a disturbance of preparing and realizing the targeted movements. The more pronounced MP changes were detected in right-side parkinsonism and frontal lobes brain tumors. Affective disorders have the least influence on MP. In PD, a clear association between motor disorders and changes of cognitive and affective functions was found.