Langerhans cell histiocytosis of the sphenoid sinus: a case report
Yu, G.; Huang, F.; Kong, L.; Kong, X.; Zhang, L.; Xu, Q.
Turkish Journal of Pediatrics 52(5): 548-551
2010
ISSN/ISBN: 0041-4301 PMID: 21434545 Document Number: 639518
Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is a rare disorder characterized by clonal proliferation and excess accumulation of pathologic Langerhans cells causing local or systemic effects. Bone is the most common organ involved and a single skull lesion is the most frequent presentation of childhood LCH. However, sphenoid sinus is an uncommon condition of involvement in LCH. Here we report a case of LCH in the sphenoid sinus, which occurred in a seven-year-old girl who presented initially with headache. The girl had suffered from headache for one month before she went to an otorhinolaryngologist one week before. Magnetic resonance imaging (MRI) showed a lesion of inflammatory granuloma. Surgery was performed and the disease was diagnosed pathologically as single-site LCH via hematoxylin-eosin (H&E) and immunohistochemical staining.