Diabetes insipidus in Langerhans' cell histiocytosis: report of a case
Wu, H.T.; Chen, B.H.; Sheen, J.M.; Chang, T.T.; Ko, S.C.
Kaohsiung Journal of Medical Sciences 15(5): 302-306
1999
ISSN/ISBN: 1607-551X PMID: 10375874 Document Number: 506645
The incidence of diabetes insipidus secondary to Langerhans' cell histiocytosis (LCH) varies among different reports, ranging from 9.5 to 50 %, but it has never been reported in literature in Taiwan. Therefore, we presented a case suffering from polyuria, polydipsia, body weight loss for more than one year and seborreic dermatitis-like skin lesions over the scalp and trunk for more than two years. Her body weight and body length were both less than 3 percentile. Fluid restriction and vasopressin test were performed to differentiate nephrogenic from neurogenic diabetes insipidus. Skin biopsy revealed picture of LCH and LCH with complete central diabetes insipidus was diagnosed. Brain MRI and other laboratory examinations were all within normal limits. She received nasal DDAVP treatment and chemotherapy with TPOG-H 94 protocol. After 3 months treatment, her skin lesions disappeared and daily urine amount returned to normal range.