2-[4- (4-Methoxyphenylcarbonyloxy) benzylidene]-6-dimethylaminomethyl cyclohexanone hydrochloride: a Mannich base which inhibits the growth of some drug-resistant strains of Mycobacterium tuberculosis
Das, S.; Das, U.; Bandy, B.; Gorecki, D.K.J.; Dimmock, J.R.
Die Pharmazie 65(11): 849-850
2010
ISSN/ISBN: 0031-7144 PMID: 21155394 Document Number: 637957
2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dime-thylaminomethyl cyclohexanone hydrochloride 1 has a MIC value of 0.78 microg/mL towards Mycobacterium tuberculosis H37Rv and displays similar or identical MIC figures towards various drug-resistant strains of this microorganism. The enone 1 along with a partial structure 2-dimethylaminomethylcyclohexanone hydrochloride 3 affected respiration in isolated rat liver mitochondria differently which may contribute to the variation in toxicity to both normal cells and M. tuberculosis.