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Using of chromatographical methods to study stability, pharmacokinetics and metabolism of propofol (review)

Adeishvili-Anguladze, L.V.; Makharadze, R.V.; Kurtsikidze, M.S.; Abuladze, N.B.; Gabuniia, K.U.

Georgian Medical News 170: 95-100

2009

ISSN/ISBN: 1512-0112
PMID: 19556652
Document Number: 637810
Propofol (somnopol, diprivan) 2,6-diisoprophilphenol is a preparation of short-term, intravenous narcosis used for local and general anaesthesia through single injection or permanent infusion with the speed of 4-12 mg/kg in an hour. In this study we tried to summarize the experience of using of chromatographical methods (gas chromatography-GCH0, high performance liquid chromatography (HPLC), thin layer chromatography (TLCH) and combination of mass-spectrometry with GCH (GCH-MC) and HPLC (HPL-MC) to study stability, pharmacokinetics and metabolism of propofol. A labour-intensive and important work have been carried out to obtain information about propofol.

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