Pharmacokinetics of propofol as an induction agents in adults
Landais, A.; Cockshott, I.D.; Coppens, M.C.; Cohn, N.; Richard, M.D.; Saint-Maurice, C.
Cahiers d'Anesthesiologie 35(6): 427-428
1987
ISSN/ISBN: 0007-9685 PMID: 3500758 Document Number: 304420
The disposition kinetics of Propofol have been determined in 7 patients (3 men, 4 women) receiving 2.5 mg/kg for induction of anaesthesia. Peripheral venous samples were collected up to 12 hours after injection of the drug. Data analysis indicates a 3 compartment model with a terminal half-life of 480 +/- 141 min, clearance of 0.0352 +/- 0.0014 l/min/kg and volume of distribution of 24.2 +/- 6.2 l/kg.