Propofol for induction of general anesthesia
Mitsukuri, S.; de Grood, P.M.; Crul, J.F.; Yokoyama, K.
Masui. Japanese Journal of Anesthesiology 37(2): 203-206
1988
ISSN/ISBN: 0021-4892 PMID: 3259638 Document Number: 314202
Propofol emulsion (2, 6-diisoprophylphenol), which is a new intravenous anesthetic agent, was used for the induction of anesthesia in 21 patients (13 males and 8 females). A bolus dose of alfentanil 0.5 .apprx. 1.0 mg or fentanyl 0.05 mg was administered 60 seconds prior to induction for the relief of vascular pain. Propofol 2mg/kg was given intravenously for induction taking over 30 seconds. Anesthesia was successfully induced after a single dose of propofol in all the patients. Apnea was observed in about 80% of patients. Approximately 40 seconds after the start of induction, patients stopped counting. Following next 10 seconds, disappearance of the eyelash reflex was observed. Mean blood pressure decreased about 20% and heart rate increased about 5% at two minutes after induction. Mild pain on injection site was noted in only one patient. Skin flash was noticed in two patients and tremor was observed in one patient. Otherwise, no serious complication was observed. Induction of anesthesia was very smooth, rapid and effective in all the patients. In conclusion, this study showed that propofol could be used as a useful induction agent without side effect.