Study of the pharmacokinetics of phosphemide in rats with the use of physico-chemical methods
Safonova, T.S.; Presnova, Z.F.; Linberg, L.F.; Chernov, V.A.; Kuriatov, N.S.
Farmakologiia i Toksikologiia 38(4): 491-494
1975
ISSN/ISBN: 0014-8318 PMID: 1213145 Document Number: 88735
A study on the passage of phosphemide with urine and distribution of the drug over the organs and tissues of intact (without fumour) rats and those with sarcoma-45 showed the bulk of unchanged drug to be excreted together with the urine during the first 3-4 hours following its intravenous and intraperitoneal administration. In rats with sarcoma-45 phosphamide is passed with urine in a somewhat greater amount than in the intact animals. With intravenous application the rate of the drug elimination in intact rats and in the ones with carcoma-45 is virtually the same, being somewhat lower with intraperitoneal injection of phosphemide.