The time course of changes in cell immunological parameters during administration of live dry plague vaccine
Bogacheva, N.V.; Darmov, I.V.; Borisevich, I.V.; Kriuchkov, A.V.; Pechenkin, D.V.
Klinicheskaia Laboratornaia Diagnostika 8: 24-27
2009
ISSN/ISBN: 0869-2084 PMID: 19827193 Document Number: 633742
The study of the time course of changes in cell immunological parameters by a magnetic separation technique in human beings during the administration of plague vaccine in relation to the immunological load revealed the higher blood levels of all T lymphocyte subpopulations on day 14 after vaccination. These changes are most typical of a primary vaccinated cohort. The increased frequency of plague vaccine administration and multiple immunizations with live plague, anthrax, and tularemia vaccines produce the time-course of changes in T lymphocyte populations (subpopulations) in response to the regular administration of plague vaccine. A high immunological load in man also promotes a significant reduction in the level of B lymphocytes.