Effect of x-ray contrast agents on the thromboresistant properties of vascular walls
Klimanova, E.V.; Makarov, V.A.; Petrukhina, G.N.; Bolotova, E.N.; Shimanovskiĭ, N.L.
Eksperimental'naia i Klinicheskaia Farmakologiia 72(2): 41-43
2009
ISSN/ISBN: 0869-2092 PMID: 19441728 Document Number: 632093
It is established that the x-ray contrast agents urografin, omnipak, and ultravist produce a dose-dependent decrease in the thromboresistant properties of vascular walls in experimental rats. This effect is determined by the individual properties of substances rater than by their belonging to a certain class of ionic or nonionic compounds. Preliminary administration of n3-polyunsaturated fatty acids from fish oil offers a significant protection against the negative action of x-ray contrast agents and retains the antiaggregant activity of the vessel wall intima.