Extraction of cholesterol from vessel walls by surface-active agents and organic solvents
Lopukhin, I.M.; Berkovich, M.A.; Piatnitskiĭ, N.N.; Archakov, A.I.; Guliaev, A.A.
Voprosy Meditsinskoi Khimii 25(1): 75-77
1979
ISSN/ISBN: 0042-8809 PMID: 425374 Document Number: 143475
Low concentrations (0.1--1.0%) of surface-active substances Tween-20, Triton X-100 and sodium deoxycholate were shown to extract 20--40% of cholesterol from dog vessel wall. Dioxane was effective at high concentrations (80--100%). As contrast to dioxane, ethanol extracted up to 20% of cholesterol at low concentrations (10--20%). The thickened intima of the atherosclerotic vessel is the significant barrier for the extraction of cholesterol.