Aporphine alkaloids from branches and leaves of Polyalthia nemoralis
Lu, Z.; Zhang, Q.; Chen, R.; Yu, D.
Zhongguo Zhong Yao Za Zhi 34(18): 2343-2345
2009
ISSN/ISBN: 1001-5302 PMID: 20030084 Document Number: 631180
To investigate the aporphine alkaloids in the branches and leaves of Polyalthia nemoralis. The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatographies. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data. Five aporphine alkaloids were isolated and identified as: bidebiline A (1), annobraine (2), lanuginosine (3), liriodenine (4), oxostephanosine (5), respectively. For the first time, Compounds 2 and 5 were obtained from Polyalthia while 1, 3 and 4 isolated from this plant. The bioassays in vitro against five human tumor cell lines with MTT method showed moderate cytotoxic activities (IC50 1 mg x L(-1)) of compounds 3-5.