Novel Onchocerca volvulus filaricides from Carapa procera, Polyalthia suaveolens and Pachypodanthium staudtii
Titanji, V.P.; Evehe, M.S.; Ayafor, J.F.; Kimbu, S.F.
Acta Leidensia 59(1-2): 377-382
1990
ISSN/ISBN: 0065-1362 PMID: 2378219 Document Number: 366691
The identification of filaricides in 3 medicinal plants is reported. The compounds carapolide A, mexicanolide-methylangolensate mixture from C. procera and oliverine from Polyalthia suaveolens or Pachypodanthium staudtii when tested at 10-100 micro g/ml were found to exhibit considerable microfilaricidal activity after 24 h of incubation. Oliverine was found to be filaricidal when tested against adult female O. volvulus at 100 micro g/ml. Preliminary toxicity studies in mice showed carapolide A and the mexicanolide-methylangolensate mixture to be relatively non-toxic, whereas, oliverine had a minimal lethal dose of 8 mg/kg bwt.