Efficacy of two plant extracts against vaginal trichomoniasis
El-Sherbini, G.T.M.; El Gozamy, B.R.; Abdel-Hady, N.M.; Morsy, T.A.
Journal of the Egyptian Society of Parasitology 39(1): 47-58
2009
ISSN/ISBN: 1110-0583 PMID: 19530609 Document Number: 629031
Trichomoniasis vaginalis is now an important worldwide health problem. Metronidazole has so far been used in treatment, but the metronidazole-resistant strains and unpleasant adverse effects have been developed. Treatment of patients with metronidazole refractory vaginal trichomoniasis constitutes a major therapeutic challenge and treatment options are extremely limited. In the present study, 33 metronidazole-resistant T. vaginalis females were treated with a combined course of metronidazole and tinidazole. Those still resistant to the combined treatment were given Commiphora molmol (Myrrh) as two capsules for six to eight successive days on an empty stomach two hours before breakfast. Also, natural plant extract purified from (Roman) was in-vitro investigated for its efficacy against T. vaginalis on fresh Diamond media. The anti-trichomoniasis vaginalis activity of both P. granatum (in-vitro) and C. molmol (in-vivo) extracts gave promising results.