Risk factors for cervical cancer in China: a case-control study
Cai, H.B.; Ding, X.H.; Zhou, Y.F.; Lie, D.M.
European Journal of Gynaecological Oncology 29(1): 72-75
2008
ISSN/ISBN: 0392-2936 PMID: 18386469 Document Number: 619867
Objectives: To determine the prevalence of human papillomavirus types and investigate the risk factors for cervical cancer in Hubei, China. Methods: We conducted a case-control study to investigate risk factors. Results: HPV DNA was detected in 94.55% of patients with cervical carcinoma, and 23.64% of control subjects. The most common HPV type in cervical cancer was HPV type 16 (81.82%), followed by HPV 58 (6.36%). HPV infected patients have a higher risk of developing cervical carcinoma, which is 75.79 times more than non-infected people. The other risks were age at first intercourse (p = 0.017) and number of live births (p = 0.032). A history of previous cytologic screening was associated with a substantial reduction in risk (p = 0.001). Conclusions: The three principal reasons that Hubei has a high rate of women developing cervical carcinoma are HPV infection, age at first sexual intercourse and number of live births. Cervical cytology screening provides efficacious protection.