A Case-Control Study on Risk Factors of Breast Cancer Among Women Attending a Tertiary Care Hospital in Kolkata, India
Chakraborty, A.
Cell Biology and Cell Metabolism 7(1): 1-6
2020
ISSN/ISBN: 2381-1943 Document Number: 572129
Backgrounds: Breast cancer is the leading cancer in female globally. Incidence of breast cancer is also found increasing in developing countries like India owing to the rapid urbanization and life style changes. Presence of multiple risk factors with their varied risk estimates in different studies has made it difficult to design a specific primary prevention program. This study aimed at identifying various factors associated with breast cancer along with estimating their risk among women from an eastern state of India. Methods: This is a Hospital based age group matched case-control study in which 66 confirmed female breast cancer cases and 264 female controls (1:4 ratios) were interviewed on various exposure status by a predesigned, pretested questionnaire. Univariate and multivariate techniques were used for the analysis of data and the risk was estimated in terms of Odds Ratio (OR) with 95% Confidence Interval (CI). Results: Nine factors (positive family history, place of residence, occupation, Body Mass Index, age of menarche, age of first delivery, duration of breastfeeding, exposure to chest X-ray and tobacco chewing) were found to be associated with breast cancer on univariate analysis. Out of them only four factors namely family history of breast cancer, exposure to chest X-Ray, exposure to chewing tobacco, and Body Mass Index ≥25, showed significant risk on multivariate analysis. Conclusion: This study identified significant risk with the factors relatively less reported like, exposure to chest X-ray, smokeless tobacco.