The role of the functional state of kidney mitochondria in predisposition of hydronephrotic rabits to gentamicin nephrotoxicity
Bushma, K.M.
Eksperimental'naia i Klinicheskaia Farmakologiia 71(3): 26-30
2008
ISSN/ISBN: 0869-2092 PMID: 18652252 Document Number: 615859
A correlation between the individual features of renal mitochondrial respiration in hydronephrotic rabbits and the degree of manifestation of gentamicin nephrotoxicity is established. The damage of kidney by the antibiotic is manifested to a greater extent in rabbits with the initial (before the administration of gentamicin) reduced ability of mitochondria to oxidize alpha-ketoglutarate, and to a lesser extent in rabbits with the reduced ability of mitochondria to oxidize palmitoilkarnitin and succinate.