The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin
Yilmaz, O.; Cabalar, M.; Ozbilgin, S.
Veterinary and Human Toxicology 41(4): 222-225
1999
ISSN/ISBN: 0145-6296 PMID: 10434375 Document Number: 501865
Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal i.m. twice daily (5 rabbits), 3 mg gentamicin/kg i.m. twice daily (5 rabbits), or 0.9% NaCl solution for 10 days (5 rabbits). The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.