Acute toxicity of bemithyl and bromithyl
Bugaeva, L.I.; Spasov, A.A.; Verovskiĭ, V.E.; Iezhitsa, I.N.
Eksperimental'naia i Klinicheskaia Farmakologiia 63(6): 53-57
2000
ISSN/ISBN: 0869-2092 PMID: 11202514 Document Number: 6114
The experiments on rats showed for bemithyl LD50 = 581.48 (350.17-965.57) mg/kg and for bromithyl LD50 = 1750.30 (1463.07-2093.92) mg/kg (males) and 1584.29 (1280.46-1960.22) mg/kg (females). The therapeutic ratios are 4-6 for both drugs, while the toxicity index is 10-15 for bemithyl and 20 <196> 22 for bromithyl. It was established that ergotropic effects prevail in the toxicity of bemithyl administered in the 20-80 mg/kg dose range, while trophotropic effects are dominating at doses above 100 mg/kg. Bromithyl exhibits a dose-dependent trophotropic effect in the entire dose range.
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