The allelic polymorhism of IL-1alpha and IL-beta genes in patients with chronic inflammatory periodontal diseases
Tsarev, V.N.; Nikolaeva, E.N.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2007(3): 43-47
2007
ISSN/ISBN: 0869-6047 PMID: 17500214 Document Number: 610611
The researchers studied the polymorphism of IL-1 alpha and 1l-beta genes in patients of different ages with severe chronic generalized periodontitis and people with healthy periodontium. They used molecular and genetic techniques such as polymerase chain reaction and reverse hybridization with Geno Type (R) PRT reagents (Germany). The study demonstrated a correlation between high frequency of genetic polymorphism in IL-1A -899 and IL-1B +3953 loci and the development of severe periodontitis in patients less than 35 years of age, and a possibility of using this parameter in complex assessment of patients with periodontal diseases. The research suggests that Geno TypeR PRT test system should be recommended for evaluation of patients with a high risk of aggressive periodontal diseases, as well as patients with therapy- resistant periodontitis.