Association of Polymorphic Markers in Genes of Innate Immunity in Patients with Periodontitis and Inflammatory Diseases of Upper Respiratory Tract
Sarkisyan, N.G.; Gankovskaya, L.V.; Tuzankina, I.A.; Svitich, O.A.; Ron, G.I.; Shershnev, V.N.; Kolyadina, O.N.; Dolgikh, M.A.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2016(1): 67-71
2016
ISSN/ISBN: 0372-9311 PMID: 27029120 Document Number: 688037
Search of association of polymorphisms in DEFB1, IL-10, TNF-α and TLR2 genes with development of chronic generalized periodontitis in representatives of Ural region (Caucasian race). 142 patients, that were split into 3 groups, took part in the study: a group of patients with periodontitis, a group with frequent inflammatory disease of upper respiratory tract and a comparison group--healthy donors. A study of polymorphic markers was carried out: DEFB1 (-44G/C), DEFB1 (-20A/G), IL-10 (-1082.A/G), TNF-α (-308 G/A), Arg753Gln and Arg677Trp using PCR in real time mode. Association of infectious pathology ofupper respiratory tract and development of periodontitis diseases with markers in DEFB1 (-44G/C) and Arg753Gln and Arg677Trp genes was determined. Significant differences in distribution of genotypes and alleles of genes IL-10 and TNF-α in the group of patients with periodontitis and comparison group were not detected. DEFB1 (-44G/C) polymorphism can be examined as a marker of periodontitis development risk.