Study of the Role of Innate Immunity Factors (Tlr2, Hbd-2, Tnf-Α, Tgf-Β) in Periodontitis Pathogenesis
Gankovskaya, L.V.; Helminskaya, N.M.; Svitich, O.A.; Molchanova, E.A.; Grechenko, V.V.; Sokolova, E.V.; Rusanova, K.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 93-97
2015
ISSN/ISBN: 0372-9311 PMID: 26950997 Document Number: 681474
Study of the role of innate immunity factors, namely, expression of TLR2 and HBD-2 genes, as well as TNF-α arid TGF-β in pathogenesis of periodontium tissue inflammation. 59 individuals with periodontitis illnesses were included into the study; 15 healthy donors represented the comparison group. Study of the TLR2 and HBD-2 gene expression levels was carried out by rRT-PCR, cytokine production evaluation--by EIA. The results of the study have shown the presence of TLR-mediated disbalance in the innate immunity system in the periodontium tissue during chronic generalized periodontitis. TLR2 gene hyperexpression was accompanied by the reduction of expression of anti-microbial peptide HBD-2, as well as an increase of production of TNF-αand TGF-P by epithelial cells of periodontium mucosa. Conclusion.-The study carried out has shown that disturbance of molecular mechanisms of innate immunity system has an important place in pathogenesis of periodontitis. -